It must be a problem getting the profile information when starting the game, that it thinks the default profile is in use...
If you rename or delete the '..Documents\Larian Studios\Divinity Original Sin 2\PlayerProfiles\playerprofiles.lsb' file before starting the game, does it bring up a list of profiles on startup, allow you to select one to use and proceed normally after that (at least until you restart)?
Try doing a clean boot and then test the game. Click Start, or hit WinKey-R, type in msconfig and hit enter; in the General tab, click Selective Startup, uncheck Load startup items (if required) and leave Load system services and Use original boot configuration options checked. Next, click on the Services tab, check the box to Hide all Microsoft services, then click the Disable All button (maybe make a note of which are currently enabled/disabled), then click OK and reboot the computer. Run msconfig again to switch back to the normal boot configuration.
Deleting playerprofiles.lsb brings menu, but profile still can't be selected. Clean boot does not change the situation either.
