So during my run of DOS2 I came across an NPC named Nicolas in the town of Driftwood here: https://imgur.com/a/V135g
Upon talking to Nicolas and exiting dialogue with him my character was unable to speak to any other NPC's or my companions. Reloading a previous save will fix the issue. I'm not sure if this bug is unique to my run of the game but I'd like to point this out just in case.