Same issue here, I posted on the steam forums in hope to get some help. http://steamcommunity.com/app/435150/discussions/6/3223871682614105719/
I started a new playthrough, but already in the boat my 1st save is 3.93mo and the 2nd some minutes later is 4.10mo, I think the issue starts from the beginning of the game until it can't load anymor and crashes. I'm unsure about how this crash is related to the fort joyr center crash and the fort joy tp crash that I got too after a while.
