From what I have noticed, for me at least, the memory leak seems to be caused by the Hilde NPC. I tried going towards the center from multiple angles and watching what NPCs are popping up. All the NPCs would load fine apart from when Hilde appeared, the game would immediately lock up and the memory usage started going up. On some older saves the game would recover, on my newer saves (about 3-5 hours deeper into the game) it would either crash or barely recover but the game would be very choppy.
I have a funny feeling it could be related to the latest update but im not too sure. The game did feel like I was getting tiny stutters around fort joy but I never really noticed it until it full on locked up on me. The oldest save was from the night before the latest update and I do not recall ever noticing any problems in fort joy then, only when I played again the following night (just after the update) did i start running into these problems.