I experienced this too - flickering / lighting bugs in the start area immediately
after character creation. This results in large portions of the screen blacked
out, depending on view angle and zoom (but not overlays like the journal or
inventory screen).
Video: https://youtu.be/FzHnyBSSPws
Saving the game, going back to the main menu and loading solved it for me.
Tested with Radeon Crimson ReLive 17.7.1 and 17.9.1 drivers,
AMD R9 390X (8GB), Windows 7-64 with August 2017 patches,
DOS2 version 3.0.141.716 and 3.0.141.999 (from GOG)
