Aetera the Eternal in the Mines?
Best bet is to cc her, lure off the wolves, or stack them all up and cc them together.
Typically what I tend to do is take teleport on 1-2 characters (I kept the gloves on one, and learned the spell on another), teleport as many characters close together, then blow them up with high damage aoe skills. Alternatively, if you have it, use the Custom-character aoe regen shield, wait for the wolves to descend, and then have as many characters as you can jump up in a turn and try to cc lock her to death.
I don't know what difficulty you are on, in Act 3 you will find a certain baddie, you will know who I'm talking about when you first fight him (please make sure to save), he's going to kick your ass horribly of you're struggling with Aetera. Just saying, it took me four tries to beat him.
To beat him, you will need a high enough initiative and to oneshot him before he transforms, temporarily change difficulty to explorer. He's going to have -base 22k health, 34k armor, and 44k magic armor on classic.
The rest of the bosses in that area will have around 6k health to 10k health to put that into perspective, and if you fail to cc him, he will regenerate about 10-14k armor or 18k magic armor (he has high perseverance). You don't need to know what I'm talking about right now, believe me, you will know it when you find it. :3
Best suggestion for most foes in combat:
Look at what they're weak to, view their weaknesses, strengths, and immunities.
Some foes will be completely immune to certain debilitating effects, and vulnerable to others.
