@Cecco
When it comes to libs installed, I have:
- from d3dx10, untill d3dx9_43 everything checked
- directx9
- vcrun2015
- xact
- xinput
- dotnet40 - is not checked, because you get error on install, that's why it's not checked.
=> so more or less same as you
What you can try is to run Lutris from console and then you will be able to see errors, maybe that can help a bit.
Additionally, in properties for DOS2 in Steam (right click -> Properties) - I have disabled both options on General tab.
In Wine configuration (right click on Lutris Game -> wine configuration), I have Windows 7 as Windows Version.
On Graphics Tab - first 3 options checked. Staging options -> all checked. (but games runs when all are unchecked too).
-= Some exp with playing =-
I have played already 18 hours. Books are problem, some of them are relevant for quests, but you can just open them and close, and quest log will get updated, also recipe books -> just open them and recipe will be added. Some books can be viewed, so I check every book if readable or not -> after that I'm selling them.

Skill books work properly. Performance is also fine.