@mtodor
Again I am very, very grateful for your assistance!

Here is what I further did and what came out:

- Matching my Lutris-wine-settings (staging-tab, graphics-tab) with yours => mouse cursor, crash

- running Lutris in the console produced this error:
"err:winediag:wined3d_adapter_init GL_ARB_compatibility not supported, requesting context with GL version 3.2."

(manually overwriting the GL version with
export MESA_GL_VERSION_OVERRIDE=3.2 doesn't help)

- Since (without override)
glxinfo | grep "OpenGL version"
produced
OpenGL version string: 3.0 Mesa 12.1.4

** THE FOLLOWING ISSUE JUST CONCERNS ARCH/ANTERGOS:

Hence I realized that something must have gone wrong when updating via console (and Pamac) on Antergos, since today's Mesa for Arch/Antergos should be Mesa 17.2.1.

There is - as I found out in the Arch forum - actually an updating issue affecting Arch/Antergos-installs from an 'old' ISO ('old' meaning before February 2017, which is my install)
being caused by 'unknown' signatures from one "Anatol Pomozov" and keeping updating from completion.

If any other Arch-user has this problem as well: The solution can be found here in the Arch Forum. (AT YOUR OWN RISK!)

When updating afterwards I ran into a ca-certificates-utils error, which is solved as described here. (AT YOUR OWN RISK!)

And while running "sudo pamac -Su" I had to apply the "Anatol Pomozov" key-ring upgrade once more.

** END OF ARCH/ANTERGOS-ONLY PROBLEM

- Now:

glxinfo | grep "OpenGL version"

shows:

"OpenGL ES 3.1 Mesa 17.2.1"

=> BUT DOS2 won't start and the selfsame problem persists with the very

"err:winediag:wined3d_adapter_init GL_ARB_compatibility not supported, requesting context with GL version 3.2."

when running Lutris from console and then EoCApp.exe in the prefix.
(Neither does "export MESA_GL_VERSION_OVERRIDE=3.2" do the trick, nor manipulating the Registry as expounded in the Wineforum-Post, we mentioned above. )

*

@mtodor
PS: Don't worry about the black books in DOS2 since we are writing the great Divinity-and-Linux-Saga here stupid