Will the Vampirism passive have multiple stages similar to ES:O (Elder Scrolls: Online)?
If yes, and you might had that already planned out. At higher stages, the affected player should be treated as an Undead aka fully clothed and not seen by NPC's.
As an additional challenge I personally think that random encounter with Vampire Hunters seems pretty nice. Don't know if it possible with the Divine Engine 2. I believe the enemies have to be on the map, regardless. That probably answers itself.
Looks pretty nice so far.