Itemization is ass, but you can use the scaling mods to remove the scaling on vitality, which reduces armor and weapon damage accordingly (as they're bound to vitality, which means Larian intentionally bloated everything), making it easier to keep good items for a long period of time. Stats on items become bloated due to the fact that, after level 9 or so, every two levels boosts vitality by another 25 - 50%, because BIG NUMBERS LOL.

Talents are hardcoded, so modders can't even add new talents or fix the old ones. Best they can do is give people more talent points or a free talent.

For me, the worst part of the game is the talents, given that the EA had less talents than DOS1, and actual release removed more talents from the EA than it added. There's like 4 - 5 talents the people actually care about, and the rest are just 'I chose this because it's the least worst'. It also completely diminishes the amount of build diversity, as talents are the most diversifying feature of the game, more than classes, spells, race, etc. Entire builds tend to be based on talents, yet we have literally nothing, and no way of adding more.