There's even one quest which - for the best ending - requires someone in the group have Pet Pal, and someone in the group to be Fane or a custom with Scholar + Mystic. Having either Scholar or Mystic on separate people doesn't work.
Unless you have outside knowledge. If you "cheat", then you can still solve it.
Treated Like Cattle - started when talking to some cows in the Driftwood fields. You need a Scholar/Mystic to understand a book you can find.