There is no challenge to earning achievements. The game itselfs offers many way of breaking the game mechanics with cheesy tactics. One-hitting everything with indestructible chest, keeping boss occupied with talking, plastering everything with barrels around boss fights, playing hit and run with sneak, sniping shot and flee, creating henchments just to steal and dispose of them afterwards... Just to mention a few. There is hardly any challenge in this challenge, if you really want those achievements regardless of mods.