Ill add my story, im not sure if it helps, but ...
My rig is old, CPU AMD Phenom II 945 3000 (OC to 3850MHz) + Mugen Max, 12 GB RAM (UC from 1333 to 1020Mhz), GPU GB Windforce 760, 2x HDD, 500W!! bronze PSU, etc + Win 10 x64 CU + all updates. I didnt have any problems with stuttering, any patch, all settings max, GPU demands very heavy, temp goes to 80°C, CPU 52°C avg.
The PC case has only one rear fan and because of GPU heat, I added another 4-pin fan on the side just above GPU card plugged to 4-pin socket. In the game GPU temp dropped avg 5°C, however i got stutter. Like periodical stutter. Like a heartbeat, pulsing. Because my CPU is OC and my PSU is only 500W i shut down system and unplugged the freshly added fan. The game runs smoothly again since then.
I didnt test any other games with that extra fan on, only DOS2, but my untested conclusion is:
- 500W PSU cant stand another device - fan (voltage limit exceeded)?
- my Gigabyte mobo doesnt like 4-pin fan?
- Windows, or just spec. CU is problematic with 4-pin fan?

IDK if this helps, I found out and registered on this forum just to let u guys know. I dont have any major problems so far, zero crashing, only last patch (3) made tooltip blinks (mouse hover over items in inv.) and some minor issues, but Larian is working hard on game updates. EN is not my native language so bear with me, thx.
cybero75