The Bethesda games do attempt to disable mods on a whim: ISTR New Vegas would disable them if the console was activated (which is very easy if like me you're not an accurate typist) and FO4 requires a F4SE plugin to re-enable them if you're using mods. It all seems rather pointless and annoying: if anything, data gathering is even more compromised by arbitrarily disabling them and it just annoys players.
