Well I finally found the issue, at least for me.
As it seems, it was an overclocked CPU.
When I went through all the possible configuration scenarios, I found this may be possible as I already observed that DOS2 is somehow weirdly written application that already had problems with my overclocked GPU (got black screen and I could only reset).
This is of course very strange behaviour, cause not a single other game I played did any problem with overclocking. After I firstly set up correct values for CPU and GPU I didnt have any BSOD, unresponding GPU drivers.
I do not understand why DOS2 is an exception here but, maybe somebody else also got overclocked CPU and wonders about stuttering/frame skips.
Try setting default values for CPU. Might help.
