Depends on what you mean by hybrid - are we talking physical/magic damage hybrid? I haven't found any combination yet that seems to outperform a pure class, no.
But if we are talking about melee/spells, there are quite a number of spells available, especially in necro/geo that either does physical damage or checks for physical armor. My DW rogue is running mosquito swarm and corrosive touch and my 2h warrior is running earthquake for instance. Still kind of fits the fantasy, and works quite well.
