Oh boy, survival mechanics. Yay. At least you've made the wise decision to quarantine them into their own separate difficulty so they don't have to infect the rest of the game.
I will point out that "only saving at waypoints" is not a great idea even for your hardcore roleplayer mode. It is annoying if you would have to stop and quit before you planned. The end of Act 1 and act 3 also have a LOT of stuff happening between waypoints which takes some time to deal with.
