There is always a way to get a quest or complete a quest without a specific tag, except the vault's one.
It's frustrating to be stranded from a whole part of an area because of your character's pick (like a lonewolf duo).
It makes scholar a must have, far from barbarian and noble for example...
An option with a ghost, a NPC who shall translate odd books (like Tarquin, he's on Lady Vengeance, he knows old languages, why shall he not translate books ?) will be pleasant !