None of the guides I have seen have finished the game yet--a testament as to how huge the game is. And then, of the areas they do finish, I have seen things omitted altogether (that I myself did, or else did differently), and lots of typos--indicating a rush...;) It'll be awhile, I suspect.
I'd recommend:
Talk to everyone
Complete every quest you can
look in every container
Maximize your skills for every character
--Basically, leave no stone unturned...;)
