I'm not sure I've played a game where I can envision so many alternate possibilities to play the game through again:

1. The standard first run.
2. Fane led all skeletal team.
3. Running each hero separate w/group of nobodies.
My only regret on my first run, bringing 4 heroes to me is not the way to play it.
4. 1 man run.
5. 6 man mod run.
6. I'm also on the side working on a 1 turn TB mod, where you only get one move period per player turn, like chess. That I think will give a whole new feel.
7. The kill everything evil team run. (Perhaps marry that with the all skeltal run.
8. The avoid combat at all costs run.

And others I've already forgotten. There are so many NPC story choices you can make in this game. It really is right up there or surpassing BG2 in that realm.

9. The Enhanced Version run, you know it's coming. That cleans up the game from start to finish and will be the legacy.
10. The all magic run.
11. The all blade run.
12. The all once class per char run.
13. Two player coop.
14. Four player coop.
Look at the mods...