No problem unless it's a party wipe, and that also ain't a problem.
The party resurrects, or in case of a party wipe and I really want to keep the characters, they are captives ready to be sacrificed or whatever.
Worst case senario: some or all players need to recerate their characters.
A bit of work, but no problem.
And most certainly not a game breaker.
We have a saying: "Where there is a will, there is a way."
We as a group have a will, and Larian has given us many many ways.