Do you have the same problem if you create a new profile and start a new game?
Can you load an old save from your current playthrough and save? If so can you then load a recent save and make a new save?
Are you shutting down all non-essential programs (especially anti-virus) before starting the game? Firewalls can cause problems during the save and load process, but usually just increasing the time taken, in the few cases reported.
