All this work seems like it's not worth it, that time could be better spent gaming
You're right, of course, and I actually used to dual-boot on my old PC. But now I stick to principles and wait either for a solution to the wine issue, or a native release, whichever comes first. While I wait, DOS2 will only get better

.
Regarding the wine issue, there's some signs of progress to be found:
https://bugs.winehq.org/show_bug.cgi?id=43890#c2 As to a native port, I would suspect Larian to target consoles with highest priority as soon as the game gets out of beta

and do Mac/Linux last, if at all. At least, that would make the most sense economically, as much as I personally dislike it.
Oh, and to answer my own question from earlier: DOS2 is a 64bit program, so it requires a 64bit wine prefix.