As already described here:

https://steamcommunity.com/app/435150/discussions/6/1620599015882513207/

The game runs quite badly after first start. And those issues reappear after longer sessions or when you change your game area [example getting from act 1 to act 2 etc].

Its supper annoying not to mention it is tied to some frame rate stutter. Wendigo source blast is the best example - the first time i load a save before that conversation the engine will always choke, frame rate will drop from 60 to 10-20 for a 1-2second, its a typical stutter/hang. And when i reload the same conversation again its fine, smooth animation, no frame drop, solid 60 fps durning the whole spell cast.
Its almost as if the engine have some issues loading some specific assets.

Same goes for the mentioned in the steam post kraken tentacle. The first time i go upstairs the animation will stutter and the audio will cut off for 1-2 seconds. Reload the save file - and everything is fine, smooth animation, no sound issues.

As for my PC config:
i5 6400 cooled by SilentiumPC Spartan 3 PRO
GTX 1050ti [evga]
8gb of ram ddr 4 [hyper fury kingston]
Mobo ASROCK B150M HDS
PSU SilentiumPC Supremo L2 550W

Nothing is OC, i have up to date drivers, i tested this issue with clean boot setup, without and with AV software on, with and without the msi afterburner and rivia tuner. I also tested the nvidia settings, pre rendered frames, power management mode set to high performance [same goes for cpu i tested the balanced as well as high performance modes].
Nothing i did changed the issue - im still able to perfectly recreate it.

Hope you guys will look into it, the game itself is awesome, but this is so damn anooying and makes it unplayable.