Its unlikely that a mac port will be made. But I have heard of people successfully running the game in Wine and Wine is available for the Mac. DOS2 currently has a silver rating on winehq which means it basically runs fine except for a minor bugs.
I dont recommend playing games using vmware or virtualbox. It will likely be annoyingly slow.
Dual booting windows is definitely the best route if Wine doesnt work to your liking. But this requires a windows license.
