Same as original poster (as far as I can tell, from their decidedly *spartan* description).
I've a Steam copy of D:OS:EE that I've played for ~20 hours, perhaps four months ago, on the same computer upon which I'm attempting to play now:
i7 7700k
2x8GBs Corsair DDR4 PC 3000 RAM
nVidia GTX1080/8GBs (390.65 drivers)
Samsung 960 Pro, 1TB
Windows 10x64 Pro
all current, official, WHQL drivers;
no overclocking/overvolting
I've erased all my old save games (*all*: including quick saves, deliberate saves and auto saves) in the hopes of starting a fresh game.
Two new characters, new game...but the game crashes after each auto save or quick save.
I have attempted:
1. Steam File Verification (successful),
2. delete contents of LevelCache folder,
3. delete entire Larian Studios folder from my Documents folder,
4. uninstall entire game, delete install folders, reinstall game fresh from Steam.
New game still crashes on attempts to save.