I guess it is one of those things I've seen elsewhere in that the evil option is often the easier and more expedient one; often there's consequences for doing so down the line, can't remember if there are in DKS or not other than a general feeling of "meh, I kinda wish I hadn't done that". In my case I try to draw a line somewhere between occasionally disreputable but without major consequences (mainly so my character doesn't end up being unrealistically saintly: not that I am myself, obviously, but being of an autistic bent I can tend to be unhelpfully black-and-white about things if I don't watch myself) but not doing things that I would consider actually unconscionable, such as actions that could be avoided which result in death (with certain exceptions for people who are unquestionably bad: which is in itself an arguably questionable opt-out) or other major problems.
An awful lot of them are grey areas though. Some people like them but I do prefer something that's more obviously right vs. wrong. Still, if they are doing shades of grey, at least they generally do them properly compared to e.g. the Tenpenny Tower quest in FO3 which was very clumsily done in that it bit you on the arse whichever way you played it.
The one that I really struggled with was being forced to choose a trainer knowing whoever wasn't chosen would be killed. Still not sure whether it was better to make the choice (especially nasty in the case of the weaponsmith which was couched pretty much as deserving vs. useful) or to leave it to the island to choose at random. There was more death in DKS than I prefer, though I admit I have a bit of an unrealistic "I want to save everyone" thing going on.
