Any Curse arrow that is used on my single-player party by the Lost Knight in the Temple of Tir-Cendelius leaves a permanent -3 to all stats debuff on that character. It persists through the end of combat, quitting and reloading the game, and Bless does NOT remove it. The only way to avoid it is to jump him at the beginning of the fight and make sure he gets no actions, since he always does it to someone on the first round, and every time it comes off cooldown.
This is maddening.