Check if have Windows Defender controlled folder access turned on (it is in "Windows Security" > "Virus and threat protection" > "Manage ransomware protection"

If you do and haven't allowed the game access to documents folder you get lots of error like this :
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FileSystem error
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Failed to delete file:
\\?\C:\Users\Hali\Documents\Larian Studios\Divinity Original Sin 2 Definitive Edition\LevelCache\fj_fortjoy_main.lsf
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OK
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You can either turn off controlled folder access or make an exception for "<Wherever>\Divinity Original Sin 2 Definitive Edition\DefEd\bin\EoCApp.exe" by clicking on "Allow an app through controlled folder access" link on the same page.

If it isn't Windows Defender it could be some other anti-ransomware doing the same thing.