An issue for me too. I look around and see people have had this problem for a long time - surprised it isn't fixed yet.

I have tried everything I can with my limited knowledge. Reinstall the game, verify game cache in steam, open the exe file with admin.

It all worked before this update, so i find this really weird. The thing is I can still open the game if in classic mode, no errors and i can create a new character and play, but I can not save or load any game. To which I have tried to switch cloud saving instead, I have tried to to delete all other saves incase those were corrupted. I have tried deleting the save game folder and creating a new one (followed a tutorial online to not screw up).

This is a really really annoying problem. I would love to play the new definitive edition, and I see a lot of people online with the same problem and I can't find any information from the devs about this? Am I just bad a googling?