Regardless of that, D:OS2 seems to run quite well under Proton. It has silver on ProtonDB and many Linux users seem to be happy with this solution:
https://www.protondb.com/app/435150Can I use Proton w/o Steam? Otherwise that would be a no-go! I guess that it's not open source, am I right?[
Proton is fully open source if you want to try and get it working on your own:
https://github.com/ValveSoftware/ProtonThat said, Steam supports running non-steam games with Proton and Lutris should be able to setup Proton for you now, though I'm not sure there's an installer for DOS2 in Lutris using Proton instead of a custom WINE build.