I have been going through DOS2 on a MacBook Pro mid 2015 MacOS 10.14.4 2.8GHz Inter Core i7
Everything was going fine until I got through a fight and started talking to characters afterwards. After one of the choices was used in the conversation popup, all other choices froze. When I hit escape, the menu came down but I could not reload or quit the game. If I tried to quit using the window button (windowed mode), I would get the menu asking if I wanted to quit but it would not respond. The only way to close the game was to do a force quit.
Apparently it is not the save file that was corrupted, because I have tried going to earlier saved files and get the same problem. At the first conversation popup you are allowed to make one choice, and then everything freezes.