I tried not only to start a new game but uninstalled and downloaded DOS2 again. I run into the same problems in a new game I started. I found that I could work the conversation by hitting return after lining up what I wanted to say with the mouse. However, mouse would not click the button. The same was true with the exit windows--I could line up with the mouse but could not click. Hitting enter caused the action to happen. I tried continuing, but found that I could not click on spells I wanted to cast or anything in the hot bar. I couldn't manipulate objects like boxes. My old saves were still existing, so it would appear that the uninstall did not delete local files.

I checked the validity of local files and they all validated. I am on Steam.