Well I do not know if it is what you want, but in Pathfinder:kingmaker you have choices that are only available for certain alignments, and lots of dialog and quest options change your alignment, so you can ban yourself for certain classes or make your LG paladin fall from grace if you play against your choice of alignment. Your barony itself also reflects your alignment.
There are games that react to your alignment and can change while you play, like nwn or Tides of Numenera.
