I cannot imagine how you can replicate 5e combat without misses. So many things are built around converting misses to hits and vice versa. Maybe they'll do the PoE thing and put grazes in, but how you then handle additional effects on hit is an issue. You can't have a fractional amount of incapacitation after being hit with a poisoned blade, for example. Unless you just make additional effects not proc on grazes, but at that point, why bother including the grazes at all, just make them misses.
Perhaps they'll have come up with something much cleverer than that though. Some sort of resource you can spend to auto-succeed on an attack roll? That would be an interesting way to handle inspiration, at least.
The statement by Vincke about misses is just a perplexing statement about 2 vastly different scenarios. Or he's not really explaining it clearly. 'Fine on tabletop, but not cool in a video game'... Why is it fine on tabletop? Why is it not fine (cool) in a game? What if he's not talking about the 5e rules at all and merely describing challenges they are having with the graphics engine?
I remember playing IWD and there was a mod used to eliminate any 'extra' attack animations unless they were a hit, in order to make the visuals look cleaner. Hits and misses were still processed behind the scenes, if you enabled the to hit info to be displayed in the info bar.