Currently there's no reason to think the issue is system related (unless you are having similar issues with other games/programs), or at least not enough to go right to reinstalling Windows. If you have a spare drive you can do a clean install on, you could try it and if it didn't help revert back to your current drive without any loss of settings or data (possibly leaving the current drive disconnected while reinstalling and testing, though if it helped you'd need both drives connected to copy over data and settings, etc; while arguably safer if you are paranoid about something going wrong with the install, having the current boot drive disconnected would add extra steps setting up a boot menu, if that helped and you wanted to be able to switch between installs to play or to move everything over to the new install).
Before resorting to that, though:
Did you move/delete the mod/GM related folders in the install folder when you reinstalled the game?
If not, try doing so, or make a copy of the DefEd folder in another location, and remove the folders from there, to test starting the game from the executable.
Try creating a new Windows administrator user account, switch to that account and try starting the game from there, directly from the executable.
Try doing a clean boot and then test the game, in the new profile or current. Click Start, or hit WinKey-R, type in msconfig and hit enter; in the General tab, click Selective Startup, uncheck Load startup items (if required) and leave Load system services and Use original boot configuration options checked. Next, click on the Services tab, check the box to Hide all Microsoft services, then click the Disable All button (maybe make a note of which are currently enabled/disabled), then click OK and reboot the computer.
Run msconfig again to switch back to the normal boot configuration.
Are you shutting down all non-essential programs (especially anti-virus) before starting the game? Firewalls can cause conflicts (generally on startup or loading screens) and overlays from graphics tweaking/monitoring programs or chat programs can also caused issues.
If you check the Event Viewer, does that give an error code or 'Faulting Module' file name that might help identify the cause of the crash?
- click Start (or WinKey-R), then type "event viewer" into the search box. in Windows 10, 'event' should bring up 'View event logs'.
- after starting the Event Viewer, expand 'Windows Logs' in the left column and select 'Application'
- in the center column, look for a recent error for the game (maybe sort by Date and Time, or search for 'EoCApp')
- check the information under the 'General' tab below the list of events, starting with "Faulting application name..."
If that doesn't help, please email supportdos2@larian.com with a dxdiag report (WinKey-R, type in dxdiag and hit enter, then when it finishes loading click on the 'Save All Information...' button and save the report somewhere handy) and a link to this topic. Also check the '..\Divinity Original Sin 2\DefEd\bin' folder for the gold.log file, and if any 'CrashDump' files are being created, zip a few together to include.
Alternately, you can post/PM a Dropbox or Google Drive link, etc.
