I would love for Larian to really work on/with the story, one aspect I have felt where dos1 and dos2 is lacking. I loved the trailer especially "Gather your party" tagline. Could have done without the spoiling of the mindflayers.
Also absolutely no scaling of course.
Static loot or in the very least everything except randon mobs drop specifik loot.
No generic crap whatsoever do the opposite of dragon age 3 and pillars of eternity. I loved dos1 an also dos2 but i did notice the stats changed from very intricate and interesting to -> +5% damage rendering 2 attributes completely insignificant and also not very interesting...
