When I watched the video, my first impression was: this is a D&D themed Original Sin, but not BG3. At the very least I would have expected a user interface that harkens back to the look and feel of the old games, and not just a quick reskin of OS2.
Also, the parts that didn't look like Original Sin reminded me a lot of Dragon Age: Origins (i.e. the cinematic dialogue or the camp). These are actually bits where Original Sin would have been closer to the original, and I am somewhat worried that the depth of characters and companions that was conveyed though BGs writing cannot be reached when every bit of dialogue needs to be acted out and motion captured.
The thing that has me worried the least are the actual game mechanics. I only have a vague idea about all the changes since D&D 2nd edition, but what I've seen felt familiar enough, and I for one am actually happy that RTwP is no more.
But my initial impression still remains: this feels like Original Sin in a slightly different setting. Somewhat reminds me of Fallout 3, which felt like futuristic Elder Scrolls but had little in common with its predecessor outside the name. And it was a bad futuristic Elder Scrolls at that. At least that seems to be less of a concern with OS3 ... oops ... BG3.
So will I want to play this? Absolutely!
Will it feel like a true successor to BG2? Hardly.