Just to be sure: a self-made character will experience the same profound stories as a custom character?
Or will self-made characters be at a disadvantage?
We do not know for sure as of now. There are articles saying that they intend for custom characters to have a more meaningful experience when compared to DOS2, but they still imply that the Origin characters will have a richer experience.
Personally I hope not, since I very much prefer to create original characters rather than playing with a preset. We shall see!