Well Sven Vincke from Larian and Mike Mearls from WoTC keep on saying that the videogame is based in D&D5e, sword coast setting, and the Baldur´s gate Adventures MiBG and DiA; not in the first games. They were very forthright even from the first interview so I kinda expected that.
Descent I knew but also Murder in Baldurs Gate? Maybe the Dead Three play a more prominent role ans the Mind Flayer thing is a red hering/side story