the tone must avoid DS2 since it is about another universe of things. I would think that different rules and stories - require different tone overall.
"Tone" is vague and unhelpful, as are similar terms like "aesthetic," "feel," "mood," "atmosphere," etc.
If you just mean is that it shouldn't look anything like DOS2, that is not only unrealistic (because that would be wasting time, effort and money recreating a lot of resources that are still fairly fresh and ready to reused and improved upon), but also moot (because it will have a resemblance to DOS2).