A game which I like a lot but which paints a rather misogynistic picture (and doesn't touch LGTB at all besides an event where gay love is mentioned and condemned in-game) is Battle Brothers:
Only men can fight (no single woman as playable char in the game), women are depicted in clichee roles such as prostitutes, damsel in distress etc.
But: this is a game that takes place in a low fantasy medieval world very similar to Europe's medieval times. So while I would oppose such behavior and views in the real world (I guess most people would do) it's okay for me in this game. Why would I be offended by a game that tries to somewhat accurately depict medieval flair? Life in general isn't worth much in this game. It's obviously a game made by nerdy men for nerdy men. No harm in that. The devs themselves don't share the views of the characters in their game.
A far as I can tell BB didn't get a lot of backlash for this rather "conservative" or clichee game/world design. The game was very successful. Most games cater to male audiences. Yet male gamers keep yelling that their views get oppressed, politics shoved down their throats etc.
What a nonsense. There are writers in the game industry that want to tell a story about something they think is worthwhile writng about. Let them. Don't tell creators what to create and what not. If you don't like the outcome then pass. It's very easy.
Yes, whats happening in the game has to fit the setting of the game. This fantasy world is not a representation of the real world.
I am not an expert for DnD lore, but Larian works together with WOTC, so I see no problem there.
We have to remember that the things that are shown in the game are not the opinion of the devs.
Just because a game has a torture scene and the one who is doing it is not shown as insane, a terrorist or the absolute evil does not mean the devs support torture.
Once again: The stuff that happens in the game and the opinions of the characters of the game has to fit the setting.
The worst thing that could happen is when the devs use a game to force their point of view on the player.
Hypothetical extrem example: The devs are against abortion. They show a doctor who does abortions as evil and insane monster and they show the psycho killer who tortures, kills and eats this doctor as the good guy.
I have absolutely no reason to assume that such things will be in the game.
Regarding gender: Game mechanic wise gender has no effect in DnD. Any char of any race or gender can have any class, background, feats or alignment.
So its only about how each char fits into this story and into this fantasy world.
Outside of romance options there are very few cases where the gender of your char had any effect on the game.
I remember:
- Only a male human noble could become king in Dragon Age Origins. All other chars could not get this ending.
- In arcanum woman had -1 str and +1 con, some races could only select males and some backgrounds were only for some race/gender combinations.
I still remember my female half elf debutante with max cha and int. She solved all problems by talking and if this was not possible she had an army of followers to fight for her.
- In Realms of Arcadia 2 you have to enter a city that is occupied by orcs. You can enter but they take away all your non magic equipment. Only woman can keep their body armor, so its good to have a all woman party because plate armor can be very expensive.
Prof. Dr. Dr. Mad S. Tist 
