I think one issue for some people is that they don't like to feel manipulated into accepting a viewpoint regardless of whether that is the writers intent or not. I can see how if you have a medium that you enjoy, whether it be video games, comic books, movies, literature, etc. some writers could come across as using the medium as a vehicle to subversively expose people to their viewpoint, in turn being disrespectful to the medium and the consumer of said medium. Nobody likes feeling used.
I would argue that no topic should necessarily be off limits if its reason for being included is to tell a compelling, engaging story, but who is able to make that determination? I would wager to think that there are some writers would claim that something is included purely for artistic merit when in truth at some level, consciously or not, they are seeking validation for themselves or their views. I also have to ask myself if somethings appears to be included for political or validation reasons is it just because it doesn't align with my own idealogical viewpoint and would I even be able to recognize something that was included for reasons other than storytelling, especially if it already aligns with me idealogically. The best propaganda isn't viewed as propaganda, at face value it just makes sense.
Creators have their own values and I feel it would be a shame for them to have to censor stories they would like to tell an order to appease those that find their values offensive. Should I clamour for Warhammer 20k to be censored because of its ultra right wing themes? Should Star Trek be banned because it presents a socialist utopia? Are either of these political/propaganda or just interesting stories?
Let's take a transgendered character for instance. I think if done right it could be a great way to explore themes of rejection, bigotry, isolation, acceptance, self-worth etc.. as well as (And I want to make it very clear that this is not a viewpoint I am endosing, non of these traits, postive or negative, am I claiming to be inherit to a trans individual) perversion, mental illness, corruption, decadence etc.. If it makes for an interesting story or character and the intent is just that and not to incite persecution or violence in real life I say to hell with those that are offended whether they are conservative, liberal, religous, racist etc.