If you create a new profile and start a new game, can you save and load properly?

Are you shutting down all non-essential programs before starting the game, especially anti-virus and any backup programs that may be monitoring the Documents folder?

Try browsing to the ~/Documents/Larian Studios/Divinity Original Sin 2 Definitive Edition/LevelCache folder and delete the contents. A corrupt file there can cause problems when saving or loading.
For the App Store version (if anyone else has similar problems), the path is: /Users/<UserName>/Library/Containers/com.larian.dos2/Data/Documents/Larian Studios/Divinity Original Sin 2 Definitive Edition/LevelCache

Try doing a clean boot and then test the game. Start/restart your Mac and hold the Shift key down as soon as the progress bar comes up in the startup window, releasing it after the desktop appears. Alternately, from the login window, hold the Shift key when you click the Log In button, and release it when you see the Dock.

Try creating a new OSX administrator user account (either with the Documents folder in the default location, or on a different drive, if available), switch to that account and try starting the game from there.


If a new game is fine, please email supportdos2@larian.com with your latest save (or a Dropbox or Google drive link, etc). If you are using any non-Larian mods, also include a list of those enabled and/or the modsettings.lsx file from your profile folder.
Each save is a folder in the '/Documents/Larian Studios/Divinity Original Sin 2 Definitive Edition/PlayerProfiles/<ProfileName>/Savegames/Story' folder.
In Finder you can zip a file or folder by right clicking on it/them and selecting compress.