If that´s your concern, in my experience with 5e the game itself it´s very newbie-friendly, there is a 3-page tryptic to show you how to do the basic things and create your character in ten minutes for a casual game or one-shot.
New players rarely read all the manuals (and usually expect the DM to explain everything else to them XD on the fly) and usually enjoy the sessions.
Even if the videogame you do not have an actual DM to do that I´m sure you can pick the basic combat and rule mechanics pretty easily because the videogame will have far less rules (about casting, short rests, roleplaying, crafting etc) and the game engine does all the "math" for you.
