Rafael_ZuB;
You cab also try updating to the latest Catalina 10.15.5 beta. It will have the latest driver updates (I know there are fixes in the Intel drivers, at least), etc.
Apple has a signup process to be able to get access to the betas. I'm not sure if there is an estimate for the public release.



AndersH;
Are there particular changes that trigger the problem again?
You can at least change the resolution and display mode by editing a configuration file, which may avoid that problem.

Edit the graphicSettings.lsx file (in the /Documents/Larian Studios/Divinity Original Sin 2 Definitive Edition' folder) in a text editor to manually change resolution and display mode.

To change the resolution, search for 'ScreenHeight', and edit the resolution in the value="xxxx" terms (shown below for 2560x1600 resolution):

<node id="ConfigEntry">
<attribute id="MapKey" value="ScreenHeight" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="1600" type="4" />
</node>
<node id="ConfigEntry">
<attribute id="MapKey" value="ScreenWidth" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="2560" type="4" />
</node>


Search for 'fake' near the start of the file to set the display mode. Edit the number in value="0" or value="1" in the second line after FakeFullscreenEnabled and / or Fullscreen; if both FakeFullscreen and Fullscreen are set to zero, it will be in Window mode).

<node id="ConfigEntry">
<attribute id="MapKey" value="FakeFullscreenEnabled" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="0" type="4" />
</node>

(and a couple entries lower)

<node id="ConfigEntry">
<attribute id="MapKey" value="Fullscreen" type="22" />
<attribute id="Type" value="0" type="5" />
<attribute id="Value" value="1" type="4" />
</node>