Regarding loot, I like BG1 most.
Finding your first weapon+1 felt importent, finally you could damage some enemies at all and weapons could not break anymore.
Unique items are very rare and feel super importent. For most of the game I used a sword+2 with extra ice damage.
BG2 was fine too, you found good items for almost every weapon type.
ToB was too epic for me. If you get a weapon+5 around every corner it does not feel importent anymore.
I think the trick is to finnd the right middle ground. Magic items should be rare so finding them feels importent, but you should find something every now and then to keep you interested.
I think its good that BG3 will be low level, so its more like BG1 than ToB.
One Problem of BG2 and pathfinder is profiency choice.
You create a char and you have to guess if you find a great longsword or a great bastard sword later, for example.
It was OK that vanilla BG1 had big weapon categories, like large swords, small swords, axes and so on.
Should not be a problem in 5E were most classes have either simple weapons or simple+martial weapons profiency.
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