If applicable, disable Steam cloud support either globally (in the client click on the Steam menu and select Settings, and then Cloud) or just for this game (in the library right click Divinity: Original Sin 2 and select Properties, then switch to the Updates tab and check the Steam Cloud section).
Alternately, exit out of the Steam client and just start the game directly from the executable when required.
Next, try browsing to the '..\Documents\Larian Studios' folder and rename the 'Divinity Original Sin 2 Definitive Edition' subfolder, then extract the replacement folder from
this download there, and see if that will let you start the game. Copying the D:OS 2 DE folder from your test user account's My Documents folder should work, as well.
The graphicSettings.lsx file is set to 1280x720 Windowed mode, Very Low quality preset and low audio quality, which you can change in the options (manually, or hit autodetect) if this gets the game to start.
If that helps, create a new profile, exit and copy a couple saves from the renamed folder into the newly created profile's ..\Savegames\Story folder. If that continues to let you start the game (and load the saves), move the rest of the saves over.
If the game still crashes, delete the replacement My Documents D:OS 2 DE folder and rename the original back again.
It is possible to run the game as a different user from your current account, if you don't want to switch accounts to play, either as a workaround or temporarily as you continue to troubleshoot why it doesn't work in your current account.
Exit the Steam client (if necessary), then hold Shift and right click the Steam shortcut and select 'Run as different user' (should work the same directly from the executable). You will then be prompted for a user name and password (you'll need to have set a password for the other account). After that, when you run the game it will save to the My Documents folder for the other account, and so should bypass the problem. You can set up a shortcut to do this automatically.
https://www.sevenforums.com/tutoria...rtcut-create-specified-program-user.htmlhttps://www.sevenforums.com/general...ly-run-shortcut-runas-w-credentials.htmlExit Steam and restart to play other games, that also save to My Documents, so you don't split the saves between your current user account and the alternate one.