Did you try lowering or raising the graphics settings, or switching to Windowed or Fake Fullscreen display mode, to see if that would make a difference?
Maybe try doing a clean boot and then test respecing. Click Start, or hit WinKey-R, type in msconfig and hit enter; in the General tab, click Selective Startup, uncheck Load startup items (if required) and leave Load system services and Use original boot configuration options checked. Next, click on the Services tab, check the box to Hide all Microsoft services, then click the Disable All button (maybe make a note of which are currently enabled/disabled), then click OK and reboot the computer.
Run msconfig again to switch back to the normal boot configuration.
If you email supportdos2@larian.com with your save (or reply/PM/email a Dropbox or Google drive link, etc) I can check it here, and reset everything. If you didn't keep playing after trying the mods it would probably be better to use a save before then, otherwise include the modsettings.lsx file from your profile folder.
Each save is a folder in the '..\Documents\Larian Studios\Divinity Original Sin 2 Definitive Edition\PlayerProfiles\<ProfileName>\Savegames\Story' folder.
In Windows Explorer you can zip a file or folder by right clicking on it/them and selecting 'Send To | Compressed (zipped) Folder'.
