What i've done so far:
- Verifying files via GOG Galaxy. By accident i've done this twice. And afterwards another time. Why? GOG Galaxy will download "some files" - 337 mb each time (took a screenshot ut couldn't find this download) - during repair / verify process. It will install "these files" afterwards and pretend that all is fine. Three times in a row. I assume that these process either is bugged or can't resolve issue. Whatever that related issue may be.
- Lowering resolution. Makes the game run much more smoother. I'm using borderless fullscreen mode and it feels great.

What i've learned so far:
I'm not sure that blank right click is related "directly" to system stress aka low or high resolution. I've managed to pick (almost?) all locks in stone garden. Only once there was a problem - after speaking to an NPC menu was blank.
On my observations i guess, that blank menu is somehow related or triggered to/by "some events". "Some" interactions with NPCs, getting some XP, running a battle, ... can make the menu (dis)appear. Reloading / restarting the game "solved" the problem (so far). Cheers to Lotrotk!

As reloading seem to solve the problem a save will not be very helpful, i guess. But i will provide some if you wanna run a test. I will send the gog-screenshot, dxdiag.txt and goldlog to support via mail. If you need some more information plz let me know.